One missense mutation was found in 48 hypertriglyceridemic patients and identified to be pro207 - leu by sequencing , pedigree analysis of this proband has been carried out and showed that the pro band ' s father is also a carrier of this mutation 征得患者家屬的同意和支持,對(duì)其家族三代十人進(jìn)行了完整的家系分析。家系分析顯示,先證者的突變來(lái)自其父親的遺傳。在外顯子6 、 7 、 8中未檢出基因突變。
The results showed as follows : ( 1 ) 6 traits are correlative with genomic factors according to analysis of population genetics and comparison of the coherence of twins . ( 2 ) the hereditary mode of rolling tongue or pointed tongue was the dominant heredity of single gene of autosome , and the can - rolling type or can - pointed type was the dominant character 本文首次從群體遺傳學(xué)、家系分析、典型系譜分析及雙生子分析多個(gè)角度并結(jié)合多種相關(guān)數(shù)理統(tǒng)計(jì)方法,對(duì)6項(xiàng)人類(lèi)學(xué)特征的遺傳方式進(jìn)行了探討,初步確定了各項(xiàng)特征的遺傳方式,評(píng)價(jià)了各特征的遺傳與環(huán)境的相對(duì)重要性。
In this article , we review isolation methods , developmental status and genetic characteristics of microsatellites , and their applications in studies on population study , pedigree analysis , assessment of genetic diversity , and construction of genetic maps in the marine mollusks , and analyzed the causes resulting to null allele , stutter bands , short allele dominance and allelic dropout , and their effects on genotyping of microsatellite 本文對(duì)海洋貝類(lèi)微衛(wèi)星分離方法、開(kāi)發(fā)現(xiàn)狀、遺傳學(xué)特性以及在種群遺傳、家系分析、遺傳多樣性評(píng)價(jià)等方面的最新研究進(jìn)展進(jìn)行了綜述,并分析了微衛(wèi)星分析中無(wú)效等位基因、 “結(jié)巴”帶、短等位基因顯性和等位基因“擴(kuò)增丟失”現(xiàn)象的產(chǎn)生原因以及對(duì)微衛(wèi)星基因型判讀帶來(lái)的影響。