For the treatment of superficial infection of griseofulvin drugs ; for the treatment of deep infection of drugs such as nystatin 用于治療淺部感染的藥物有灰黃霉素等;用于治療深部感染的藥物有制霉菌素等。
Nystatin was listed in the first class of drug catalogue for national basic medical insurance in 2000 , netilmicin sulfate and roxithromycin were listed in the second class of drug catalogue for national basic medical insurance . all its products passed china gmp inspections in 2001 . zhenyuan pharm is establishing a bulk drug center in shaoxing paojiang technological and industrial zone to create a much brighter future 目前,公司員工800余人,專業技術隊伍占三分之一,具備完整的銷售服務系統研發中心質監中心,所有原料藥制劑粉針劑生產線均通過國家gmp和iso9001質量體系iso14001環境體系的認證,羅紅霉素還取得了歐洲cos證書。
Inhibitors of cyp51 , such as azalanstat ( rs - 2i607 ) and rs - 2i745 , could inhibit the synthesis of ff - mas to decrease the accumulation of ff - mas . inhibitor of a14 - reductase , such as ay9944 - a - 7 , could inhibit the metabolism of ff - mas to increase the accumulation of ff - mas ; and some other reagents , such as nystatin , could combine with the downstream intermediate in the cholesterol biosynthesis pathway to accumulate mas . in this study , we investigated the role of mas by using these reagents to change the level of endogenous ff - mas 抑制cyp51酶的抑制劑,如azalanstat ( rs - 21607 )和rs - 21745等,均能抑制mas的合成,降低mas的積累;而抑制14 -還原酶的抑制劑,如ay9944 - a - 7等,能抑制ff - mas向t - mas的轉化而造成ff - mas的積累;還有一些物質,如制霉菌素,能阻止mas向下游的代謝而造成其積累,本文主要通過應用這些物質降低、或增加組織細胞中內源性mas的積累,來研究mas的作用。
Using the mouse fetal ovary serum - free culture model , fetal ovaries from 14 day post coitus ( 14 dpc ) mouse were cultured , and treated by ay9944 - a - 7 , nystatin and rs - 21745 . the results showed that 0 . 025 , 0 . 0625 and 0 . 125 um ay9944 - a - 7 or 25 , 50 and 75 iu / ml nystatin increased the total number of follicles per ovary significantly ; however , ay9944 - a - 7 and nystatin at the same doses could n ' t cause the same effect on the number of growing follicles and the average diameter of five largest follicles per ovary . 50 u . m rs - 21745 decreased the total number of follicles , the number of growing follicles and diameter of follicles per ovary significantly after 48 h 首先利用小鼠胚胎卵巢的體外無血清培養模型,培養妊娠14天( 14daypost - coitus , 14dpc )小鼠胚胎卵巢,分別添加能促進mas積累的ay9944 ,制霉菌素,和能抑制mas產生的rs - 21745進行處理,結果表明: 0 . 025 、 0 . 0625利0 . 125 m的ay9944 - a - 7與25 、 50和75iu ml的制霉菌素能顯著提高卵巢中形成卵泡的總數量,但是對生長卵泡數和卵泡直徑的作用不同;而mas合成抑制劑rs - 21745能夠顯著降低形成卵泡的總數量。
英文解釋
an antifungal and antibiotic (trade names Mycostatin and Nystan) discovered in New York State; derived from soil fungi actinomycetes 同義詞:Mycostatin, Nystan,