Like calmodulin and troponin c , caltractin contains four potential calcium - binding sites of predicted helix - loop - helix or ef - hand structure . with the development of technology in biology , more and more academicians study questions for discussion by mutating genes in organisms 中心蛋白的結(jié)構(gòu)類似于鈣調(diào)蛋白、肌鈣蛋白c的結(jié)構(gòu),含有四個(gè)ef - hand ( helix - loop - helix )結(jié)構(gòu),即四個(gè)鈣結(jié)合位點(diǎn)。
Rt - pcr revealed that two basic helix - loop - helix ( bhlh ) genes , mash - 1 and ngn - 1 , were up - regulated during the differentiation stage of wnt - 1 - overexpressing p19 cells . these results suggest that the wnt - 1 gene promotes neuronal differentiation and inhibits gliogenesis during the neural differentiation of p19 cells , and that neural bhlh genes might be involved in this process 我們的實(shí)驗(yàn)結(jié)果提示, wnt - 1基因可能參與了p19細(xì)胞神經(jīng)分化過(guò)程中的命運(yùn)決定, wnt - 1基因能促進(jìn)神經(jīng)元細(xì)胞的分化,而抑制神經(jīng)膠質(zhì)細(xì)胞的產(chǎn)生;神經(jīng)bhlh基因可能與p19細(xì)胞神經(jīng)命運(yùn)決定和神經(jīng)細(xì)胞分化有關(guān)。