Liver is the main organ for drug metabolism , it nearly have all ugt isozymes 肝臟是葡醛酸綴合反應(yīng)的主要場所,幾乎含有所有的ugt同工酶。
Now transgenic cell lines that express the protein encoded by ugt gene were broadly used instead of liver microsomes . the enzyme expressed in cell lines helps to realize the function of a specific gene and will provide direct information related to the isozyme interested ‘為解決上述問題,國際上人們己經(jīng)廣泛采用建立各種ugt轉(zhuǎn)基因細(xì)胞系的方式試驗,在明確基因構(gòu)成的倩況下直接獲得由特定基因所表達(dá)的ugt同工酶, fi什對性地研究該酶對藥物的代謝作用。