The research by dr lam and his collaborators from university of california , san francisco and genetech , inc . which was published in nature , a world s leading scientific journal , identifies an activating mutation in the smoothened ( smo ) gene in sporadic bccs 的科學家合作研究,發現從散發性基底細胞瘤病例中鑒定出圓滑蛋白基因的一種活化突變,使圓滑蛋白基因變成腫瘤基因,導致基底細胞瘤的出現。